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PhD

Name Dr Spencer Polley
Address 117 Movers Lane
IG11 7UQ Barking Essex
United Kingdom
Telephone 02084918193
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Presentation An interest in vaccine development and human health has led me to the field of malaria research at the London School of Hygiene and Tropical Medicine. Through combining recombinant protein expression, immunology, and population genetics, I have pursued the search for malarial antigens that are the target of protective immune responses in humans. I have recently extended my research to identifying and validating malarial drug targets through gene knock out technologies coupled with biochemical and drug assays. It is my aim to apply these skills to the search for therapeutic compounds that are of direct relevance to human health within an industrial setting.
Degree PhD
Publications Polley S, Pearce RJ (In press) Population genetics and Human Health. In: Kirch W, editor. Encyclopedic Reference of Public Health. Heidelberg: Springer Verlag Gmbh.

Polley SD, Tetteh KA, Lloyd KM, Akpogheneta OJ, Greenwood BM et al. (In Press) Plasmodium falciparum Merozoite Surface Protein 3 Is a Target of Allele-Specific Immunity and Alleles Are Maintained by Natural Selection. Journal of Infectious Diseases.

Polley SD, Conway DJ, Cavanagh DR, McBride JS, Lowe BS et al. (2006) High levels of serum antibodies to merozoite surface protein 2 of Plasmodium falciparum are associated with reduced risk of clinical malaria in coastal Kenya. Vaccine 24: 4233-4246.

Polley SD, Weedall GD, Thomas AW, Golightly LM, Conway DJ (2005) Orthologous gene sequences of merozoite surface protein 1 (MSP1) from Plasmodium reichenowi and P. gallinaceum confirm an ancient divergence of P. falciparum alleles. Molecular and Biochemical Parasitology 142: 25-31.

Ord R, Polley S, Tami A, Sutherland CJ (2005) High sequence diversity and evidence of balancing selection in the Pvmsp3alpha gene of Plasmodium vivax in the Venezuelan Amazon. Molecular and Biochemical Parasitology 144: 86-93.

Polley SD, Sutherland CJ, McRobert L (2004) Vaccination for vivax malaria: targeting the invaders. Trends in Parastiology 20: 99-102.

Polley SD, Mwangi T, Kocken CH, Thomas AW, Dutta S et al. (2004) Human antibodies to recombinant protein constructs of Plasmodium falciparum Apical Membrane Antigen 1 (AMA1) and their associations with protection from malaria. Vaccine 23: 718-728.

Cavanagh DR, Dodoo D, Hviid L, Kurtzhals JA, Theander TG et al. (2004) Antibodies to the N-terminal block 2 of Plasmodium falciparum merozoite surface protein 1 are associated with protection against clinical malaria. Infection and Immunity 72: 6492-6502.

Mattick C, Dewin D, Polley S, Sevilla-Reyes E, Pignatelli S et al. (2004) Linkage of human cytomegalovirus glycoprotein gO variant groups identified from worldwide clinical isolates with gN genotypes, implications for disease associations and evidence for N-terminal sites of positive selection. Virology 318: 582-597.

Kimbi HK, Tetteh KK, Polley SD, Conway DJ (2004) Cross-sectional study of specific antibodies to a polymorphic Plasmodium falciparum antigen and of parasite antigen genotypes in school children on the slope of Mount Cameroon. Transactions of the Royal Society of Tropical Medicine and Hygiene 98: 284-289.

Polley SD, Chokejindachai W, Conway DJ (2003) Allele frequency-based analyses robustly map sequence sites under balancing selection in a malaria vaccine candidate antigen. Genetics 165: 555-561.

Polley SD, Tiku PE, Trueman RT, Caddick MX, Morozov IY et al. (2003) Differential expression of cold- and diet-specific genes encoding two carp liver delta 9-acyl-CoA desaturase isoforms. American Journal of Physiology, Regulatory and Integrated Compl Physiology 284: R41-50.

Polley SD, Tetteh KK, Cavanagh DR, Pearce RJ, Lloyd JM et al. (2003) Repeat sequences in block 2 of Plasmodium falciparum merozoite surface protein 1 are targets of antibodies associated with protection from malaria. Infection and Immunity 71: 1833-1842.

Muhia DK, Swales CA, Eckstein-Ludwig U, Saran S, Polley SD et al. (2003) Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum. Journal of Biological Chemistry 278: 22014-22022.

Conway DJ, Polley SD (2002) Measuring immune selection. Parasitology 125 Suppl: S3-16.

Cossins AR, Murray PA, Gracey AY, Logue J, Polley S et al. (2002) The role of desaturases in cold-induced lipid restructuring. Biochemical Society Transactions 30: 1082-1086.

Polley SD, Conway DJ (2001) Strong diversifying selection on domains of the Plasmodium falciparum apical membrane antigen 1 gene. Genetics 158: 1505-1512.

Polley SD, Caddick MX (1996) Molecular characterisation of meaB, a novel gene affecting nitrogen metabolite repression in Aspergillus nidulans. FEBS Letters 388: 200-205.
Current employer London School of Hygiene & TM
Current position Research Fellow
Working experience 7 year(s)
Availability Sep 21, 2017
 
Education
1993 BSc Hons 2:1
The University of Nottingham, Nottingham
1997 PhD
The University of Liverpool, Liverpool
 
Previous positions
1997 - 1998 Research Assistant
Liverpool University
1998 - 1999 Research Associate
London School of Hygiene & TM
1999 - 2005 Research Fellow
London School of Hygiene & TM
2005 - 2007 Research Fellow
London School of Hygiene & TM
 
Created Feb 10, 2007 19:18:40
Last modified Feb 12, 2007 12:53:34